BDBM354318 1-(4-((2-((3-(Cyclopropylsulfonyl)-5-methoxyphenyl)amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)-3-(1-(3-((dimethylphosphoryl)methyl)phenyl)-3-isopropyl-1H-pyrazol-5-yl)urea::US9796742, Example 46

SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4cccc(CP(C)(C)=O)c4)C(C)C)c4ccccc34)n2)cc(c1)S(=O)(=O)C1CC1

InChI Key InChIKey=QHTHAEPYCKJRGP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 354318   

TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 354318BDBM354318(1-(4-((2-((3-(Cyclopropylsulfonyl)-5-methoxyphenyl...)
Affinity DataIC50: 1.60E+3nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3 enzyme isoform (Invitrogen), are evaluated by determining the level of acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent