BDBM400145 N-(3-chloro-4,5-difluorophenyl)-7-(2-((3,3-difluoro-1-(methylcarbamoyl)cyclobutyl)amino)-2-oxoacetyl)-6-methyl-2,3-dihydro-1H-pyrrolizine-5-carboxamide::US10328053, Compound 129::US10874640, Compound 129::US20230270719, Compound 129

SMILES CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2cc(F)c(F)c(Cl)c2)n2CCCc12

InChI Key InChIKey=YQHNAELNLHMQLC-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 400145   

TargetCapsid protein(HBV-C)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 400145BDBM400145(US10328053, Compound 129 | N-(3-chloro-4,5-difluor...)
Affinity DataEC50:  20.4nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent

TargetSodium/bile acid cotransporter(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 400145BDBM400145(US10328053, Compound 129 | N-(3-chloro-4,5-difluor...)
Affinity DataEC50:  20.4nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2023
Entry Details
US Patent

TargetSodium/bile acid cotransporter(Human)
Gilead Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 400145BDBM400145(US10328053, Compound 129 | N-(3-chloro-4,5-difluor...)
Affinity DataEC50:  20.4nMAssay Description:A HepG2 cell line overexpressing the HBV virus attachment receptor sodium-taurocholate cotransporting polypeptide (NTCP) was grown to confluency in D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/11/2020
Entry Details
US Patent