BDBM50001533 CHEMBL3237448::US8841312, 200

SMILES C1CCC(C1)n1c2nnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12

InChI Key InChIKey=BOEVQFOAJBRYBJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50001533   

TargetCyclin-dependent kinase 6(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 50001533BDBM50001533(CHEMBL3237448 | US8841312, 200)
Affinity DataIC50: 13nMpH: 7.4 T: 2°CAssay Description:The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2015
Entry Details
US Patent

TargetCyclin-dependent kinase 4(Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 50001533BDBM50001533(CHEMBL3237448 | US8841312, 200)
Affinity DataIC50: 36nMpH: 7.4 T: 2°CAssay Description:The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2015
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50001533BDBM50001533(CHEMBL3237448 | US8841312, 200)
Affinity DataIC50: 51nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50001533BDBM50001533(CHEMBL3237448 | US8841312, 200)
Affinity DataIC50: 95nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50001533BDBM50001533(CHEMBL3237448 | US8841312, 200)
Affinity DataIC50: 4.78E+3nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin) using histone H1 as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50001533BDBM50001533(CHEMBL3237448 | US8841312, 200)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2015
Entry Details Article
PubMed