BDBM50205635 CHEMBL3898133

SMILES Cc1cc(C)c(CNC(=O)c2cc(-c3ccc(N4CCNCC4)nc3)cc3c2C(C)CN3C2CCCC2)c(=O)[nH]1

InChI Key InChIKey=WZMNJYXLTFTXGO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50205635   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Integral Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205635BDBM50205635(CHEMBL3898133)
Affinity DataIC50: 378nMAssay Description:Inhibition of human wild type EZH2 using histone H3 as substrate after 1 hr in presence of 3H-SAM by filter paper detection analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Integral Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205635BDBM50205635(CHEMBL3898133)
Affinity DataIC50: 378nMAssay Description:Inhibition of human wild type EZH2 using histone H3 as substrate after 1 hr in presence of 3H-SAM by filter paper detection analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH1(Human)
Integral Biosciences

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50205635BDBM50205635(CHEMBL3898133)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of human EZH1 complex using histone H3 as substrate after 1 hr in presence of 3H-SAM by filter paper detection analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed