BDBM102617 US8536172, I-66

SMILES CS(=O)(=O)C1CCN(CC1)c1cccc2n(ncc12)-c1ccnc(N[C@H]2CC[C@H](O)CC2)n1

InChI Key InChIKey=SSWFFPALFQMQLE-QAQDUYKDSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 102617   

TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM102617(US8536172, I-66)
Affinity DataIC50:  5.80nMpH: 7.5Assay Description:JNK activity was measured by phosphorylation of GST-ATF2 (19-96) with [gamma-33P] ATP.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM102617(US8536172, I-66)
Affinity DataIC50:  16.7nMpH: 7.5Assay Description:JNK activity was measured by phosphorylation of GST-ATF2 (19-96) with [gamma-33P] ATP.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Roche Palo Alto

US Patent
LigandPNGBDBM102617(US8536172, I-66)
Affinity DataIC50:  6nMAssay Description:Inhibition of human JNK1alpha1 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102617(US8536172, I-66)
Affinity DataIC50:  17nMAssay Description:Inhibition of human JNK2alpha2 using GST-tagged ATF2 as substrate preincubated for 10 mins prior to substrate addition measured after 30 mins by micr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10/8/9(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM102617(US8536172, I-66)
Affinity DataIC50:  290nMAssay Description:Inhibition of JNK-mediated c-Jun activation in TNFalpha-induced human SW1353 cells preincubated for 30 mins prior to TNFalpha treatment measured afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed