BDBM104500 US8575114, I-12

SMILES Cc1cc2nn(Cc3cc(ccc3Cl)[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c(=O)n2cc1Cl

InChI Key InChIKey=LIKSGJKEDNKMAF-FTWQHDNSSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 104500   

TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Albany Molecular Research

US Patent
LigandPNGBDBM104500(US8575114, I-12)
Affinity DataIC50:  36.6nMAssay Description:The inhibitory activity of the compounds of this invention against the SGLT-1 or SGLT-2 transporters.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Albany Molecular Research

US Patent
LigandPNGBDBM104500(US8575114, I-12)
Affinity DataIC50: >9.00E+4nMAssay Description:The inhibitory activity of the compounds of this invention against the SGLT-1 or SGLT-2 transporters.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Albany Molecular Research

US Patent
LigandPNGBDBM104500(US8575114, I-12)
Affinity DataIC50:  33nMAssay Description:Inhibition of human SGLT2 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Albany Molecular Research

US Patent
LigandPNGBDBM104500(US8575114, I-12)
Affinity DataIC50: >9.00E+4nMAssay Description:Inhibition of human SGLT1 expressed in CHOK1 cells assessed as inhibition of [14C]-AMG uptake after 3 hrs by microbeta scintillation counting analysi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM104500(US8575114, I-12)
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM104500(US8575114, I-12)
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM104500(US8575114, I-12)
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM104500(US8575114, I-12)
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM104500(US8575114, I-12)
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Amri

Curated by ChEMBL
LigandPNGBDBM104500(US8575114, I-12)
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed