BDBM11318 1,3,8-trihydroxy-6-methyl-9,10-dihydroanthracene-9,10-dione::1,3,8-trihydroxy-6-methylanthra-9,10-quinone::CHEMBL289277::Emodin::US20230364057, Compound 242::med.21724, Compound 24
SMILES Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1
InChI Key InChIKey=RHMXXJGYXNZAPX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 45 hits for monomerid = 11318
Affinity DataKi: 770nMAssay Description:Inhibition of binding of 17 beta-estradiol to human Estrogen receptor alphaMore data for this Ligand-Target Pair
Affinity DataKi: 1.50E+3nMAssay Description:Inhibition of binding of 17 beta-estradiol to human Estrogen receptor betaMore data for this Ligand-Target Pair
Affinity DataKi: 1.50E+3nMAssay Description:Inhibition of CK2alpha (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 1.85E+3nM ΔG°: -7.74kcal/molepH: 7.5 T: 22°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...More data for this Ligand-Target Pair
Affinity DataKi: 1.85E+3nM ΔG°: -7.74kcal/mole IC50: 890nMpH: 7.5 T: 22°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...More data for this Ligand-Target Pair
Affinity DataKi: 1.90E+3nMAssay Description:Inhibition of CK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2.11E+3nMAssay Description:Uncompetitive inhibition of human recombinant aldose reductase expressed in Escherichia coli using DL-glyceraldehyde as substrate by double reciproca...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]PSB0413 from human platelet P2Y12 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 7.60E+5nMAssay Description:Inhibition of human Neu2 assessed as MuNANA substrate hydrolysis in presence of 0.1% Triton X-100 by discontinuous fluorimetric assayMore data for this Ligand-Target Pair
TargetProtein tyrosine phosphatase type IVA 3(Human)
Korea Research Institute of Bioscience and Biotechnology
Curated by ChEMBL
Korea Research Institute of Bioscience and Biotechnology
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of PRL3 after 1 hr by DiFMUP assayMore data for this Ligand-Target Pair
TargetProtein tyrosine phosphatase type IVA 3(Human)
Korea Research Institute of Bioscience and Biotechnology
Curated by ChEMBL
Korea Research Institute of Bioscience and Biotechnology
Curated by ChEMBL
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of PRL-3-mediated cell migration in human DLD1 cells after 15 hrs by crystal violet staining based microscopic assayMore data for this Ligand-Target Pair
TargetProtein tyrosine phosphatase type IVA 3(Human)
Korea Research Institute of Bioscience and Biotechnology
Curated by ChEMBL
Korea Research Institute of Bioscience and Biotechnology
Curated by ChEMBL
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of PRL-3-mediated cell invasion in human DLD1 cells after 20 hrs using crystal violet staining by Matrigel invasion assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of binding of 17 beta-estradiol to human Estrogen receptor alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20E+4nMAssay Description:Compound was tested for the enzyme inhibitory activity against Human Leukocyte Elastase (HLE) at 53 uM concentrationMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of binding of 17 beta-estradiol to human Estrogen receptor alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 2.69E+3nMAssay Description:Inhibition of human recombinant aldose reductase expressed in Escherichia coli using DL-glyceraldehyde as substrate in presence of NADPH by spectroph...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human recombinant ACE2More data for this Ligand-Target Pair
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of recombinant human CYP1A1 expressed in supersomes using 7-ethoxyresorufin O-deethylation as substrate after 5 mins in presence of NADP+ ...More data for this Ligand-Target Pair
TargetCasein kinase II subunit alpha/beta(Human)
Instituto Universitario De Bio-Org£Nica Antonio Gonz£Lez (Cibican)
Curated by ChEMBL
Instituto Universitario De Bio-Org£Nica Antonio Gonz£Lez (Cibican)
Curated by ChEMBL
Affinity DataIC50: 580nMAssay Description:Inhibition of human CK2-alpha/beta expressed in Escherichia coli BL21(DE3) using RRRDDDSDDD peptide as substrate after 15 mins by capillary electroph...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Affinity DataEC50: 2.00E+5nMAssay Description:This is a review article.More data for this Ligand-Target Pair
Affinity DataIC50: 1.69E+4nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase SAM siteMore data for this Ligand-Target Pair
Affinity DataIC50: 7.98E+4nMAssay Description:Inhibition of Dengue virus type 2 NS5 RNA methyltransferase SAM site with 0.1 % TX100More data for this Ligand-Target Pair
TargetProteasome subunit beta type-2(Human)
Institute of Agricultural and Food Biotechnology
Curated by ChEMBL
Institute of Agricultural and Food Biotechnology
Curated by ChEMBL
Affinity DataIC50: 2.09E+4nMAssay Description:Inhibition of trypsin-like activity of human 26S proteasome assessed as decrease in AMC hydrolysis using Ac-Arg-Leu-Arg-AMC as substrate incubated fo...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-5(Human)
Institute of Agricultural and Food Biotechnology
Curated by ChEMBL
Institute of Agricultural and Food Biotechnology
Curated by ChEMBL
Affinity DataIC50: 1.22E+3nMAssay Description:Inhibition of chymotrypsin-like activity of human 26S proteasome assessed as decrease in AMC hydrolysis using Suc-Leu-Leu-Val-Tyr-AMC as substrate in...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-1(Human)
Institute of Agricultural and Food Biotechnology
Curated by ChEMBL
Institute of Agricultural and Food Biotechnology
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibition of caspase-like activity of human 26S proteasome assessed as decrease in fluorescence using Z-Nle-Pro-Nle-Asp-aminoluciferin as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of bovine kidney alpha-fucosidase using PNPG as substrate incubated for 10 mins by spectrophotometric methodMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of acid-mediated aggregation of TTR V30M mutant (unknown origin) expressed in Escherichia coli pretreated for 30 mins at pH 7 followed by ...More data for this Ligand-Target Pair
TargetDNA gyrase inhibitor(Escherichia coli (strain K12))
The Florida International University Board of Trustees
US Patent
The Florida International University Board of Trustees
US Patent
Affinity DataIC50: 1.25E+5nMAssay Description:SDFQ HTS primary assay using pAB1_FL905 was performed in 2 µL of (1 xDNA gyrase buffer: 20 mM Tris-Acetate pH 7.9, 50 mM KAc, 10 mM MgCl2, 2 mM DTT, ...More data for this Ligand-Target Pair
TargetDNA gyrase inhibitor(Escherichia coli (strain K12))
The Florida International University Board of Trustees
US Patent
The Florida International University Board of Trustees
US Patent
Affinity DataIC50: 1.25E+5nMAssay Description:SDFQ HTS primary assay using pAB1_FL905 was performed in 2 µL of (1 xDNA gyrase buffer: 20 mM Tris-Acetate pH 7.9, 50 mM KAc, 10 mM MgCl2, 2 mM DTT, ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of SARS-CoV 2 spike glycoproteinMore data for this Ligand-Target Pair
Affinity DataIC50: 4.32E+3nMAssay Description:Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 20 mins by fluorescence ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.24E+3nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cells using kynuramine as substrate after 20 mins by fluorescence ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.22E+4nMAssay Description:Inhibition of human CYP1A1More data for this Ligand-Target Pair
Affinity DataIC50: 3.73E+3nMAssay Description:Inhibition of human CYP1B1More data for this Ligand-Target Pair
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University College London
Curated by ChEMBL
University College London
Curated by ChEMBL
Affinity DataIC50: 4.53E+3nMAssay Description:Inhibition of FTO (unknown origin) demethylation activity using m6A7-Broccoli RNA as substrate incubated for 3 mins under shaking condition and measu...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of recombinant human Pim1More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of GST-fused human recombinant CK2alpha expressed in Escherichia coli HMS174 (DE3)More data for this Ligand-Target Pair
Affinity DataIC50: 3.64E+4nMAssay Description:Inhibition of sEH (unknown origin) assessed as 6-methoxy-2-naphthaldehyde formation by fluorometry assay using 40 uM cyano-(6-methoxy-naphthalen-2-yl...More data for this Ligand-Target Pair
Affinity DataIC50: 1.85E+4nMAssay Description:Inhibition of p56 lckMore data for this Ligand-Target Pair
TargetAccessory gene regulator protein A(Staphylococcus aureus)
University of North Carolina At Greensboro
Curated by ChEMBL
University of North Carolina At Greensboro
Curated by ChEMBL
Affinity DataIC50: 1.71E+4nMAssay Description:Inhibition of AGR quorum sensing system in methicillin-resistant Staphylococcus aureus AH2759 incubated for 15 hrs by P3-LUX reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.50E+5nMAssay Description:Inhibitory activity against HRV 3Cpro using HPLC assayMore data for this Ligand-Target Pair
Target3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ(Francisella tularensis)
Brookhaven National Laboratory
Brookhaven National Laboratory
Affinity DataIC50: 4.31E+4nMpH: 7.0 T: 25°CAssay Description:The enzymatic activities of FtFabZ and YpFabZ were determined via the reportedspectrophotometric method using the substrate analogue crotonoyl-CoA.7 ...More data for this Ligand-Target Pair
Target3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ [1-175](Yersinia pestis)
Brookhaven National Laboratory
Brookhaven National Laboratory
Affinity DataIC50: 2.97E+4nMpH: 7.0 T: 25°CAssay Description:The enzymatic activities of FtFabZ and YpFabZ were determined via the reportedspectrophotometric method using the substrate analogue crotonoyl-CoA.7 ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.73E+3nMAssay Description:Inhibition of recombinant human CYP1A2 expressed in supersomes using 7-ethoxyresorufin O-deethylation as substrate after 5 mins in presence of NADP+ ...More data for this Ligand-Target Pair