BDBM11434 4-[(5-{[4-(diethylamino)cyclohexyl]amino}-3-(propan-2-yl)pyrazolo[1,5-a]pyrimidin-7-yl)amino]-N,N-dimethylbenzene-1-sulfonamide::pyrazolo[1,5-a]pyrimidine 9g

SMILES CCN(CC)[C@H]1CC[C@@H](CC1)Nc1cc(Nc2ccc(cc2)S(=O)(=O)N(C)C)n2ncc(C(C)C)c2n1

InChI Key InChIKey=IXWVFGNWJLEFIG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 11434   

TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Vernalis (R&D)

LigandPNGBDBM11434(4-[(5-{[4-(diethylamino)cyclohexyl]amino}-3-(propa...)
Affinity DataIC50: 92nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified CDK2/Cyclin A was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2006
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Rat)
Martin-Luther-University Halle-Wittenberg

LigandPNGBDBM11434(4-[(5-{[4-(diethylamino)cyclohexyl]amino}-3-(propa...)
Affinity DataIC50: 5.00E+4nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2006
Entry Details Article
PubMed