BDBM14796 Pyrazole carboxylic ester 19::ethyl 1-(4-aminophenyl)-3,5-dimethyl-1H-pyrazole-4-carboxylate

SMILES CCOC(=O)c1c(C)nn(c1C)-c1ccc(N)cc1

InChI Key InChIKey=FIEYZIRYXYDMSK-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 14796   

LigandPNGBDBM14796(Pyrazole carboxylic ester 19 | ethyl 1-(4-aminophe...)
Affinity DataIC50:  350nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM14796(Pyrazole carboxylic ester 19 | ethyl 1-(4-aminophe...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human His-tagged PDE4D catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Vrije Universiteit Amsterdam

Curated by ChEMBL
LigandPNGBDBM14796(Pyrazole carboxylic ester 19 | ethyl 1-(4-aminophe...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human His-tagged PDE4D catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
LigandPNGBDBM14796(Pyrazole carboxylic ester 19 | ethyl 1-(4-aminophe...)
Affinity DataIC50:  160nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair