BDBM15247 7-chloro-11,17-dioxa-2,4,20,22-tetraazatricyclo[16.3.1.0^{5,10}]docosa-1(21),5(10),6,8,18(22),19-hexaen-3-one::macrocyclic inhibitor 5a

SMILES Clc1ccc2OCCCCCOc3cncc(NC(=O)Nc2c1)n3

InChI Key InChIKey=JRSWWYITYIOHOP-UHFFFAOYSA-N

Data  1 KI  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 15247   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM15247(7-chloro-11,17-dioxa-2,4,20,22-tetraazatricyclo[16...)
Affinity DataKi:  7.90nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM15247(7-chloro-11,17-dioxa-2,4,20,22-tetraazatricyclo[16...)
Affinity DataIC50:  10nMpH: 7.4 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 5uM ATP/[gamma-33P] ATP. 33P incor...More data for this Ligand-Target Pair