BDBM15408 2,5-dichloro-N-[4-hydroxy-3-(2-hydroxynaphthalen-1-yl)phenyl]benzene-1-sulfonamide::CHEMBL371915::naphthol compound 11

SMILES Oc1ccc(NS(=O)(=O)c2cc(Cl)ccc2Cl)cc1-c1c(O)ccc2ccccc12

InChI Key InChIKey=KDKVLAFZMJRTEA-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 15408   

TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM15408(2,5-dichloro-N-[4-hydroxy-3-(2-hydroxynaphthalen-1...)
Affinity DataIC50:  700nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM15408(2,5-dichloro-N-[4-hydroxy-3-(2-hydroxynaphthalen-1...)
Affinity DataIC50:  700nMAssay Description:Inhibition of Hsp90 in human SKBR3 cells assessed as interaction with Cy3b-conjugated geldanamycin by FP assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Emory University

Curated by ChEMBL
LigandPNGBDBM15408(2,5-dichloro-N-[4-hydroxy-3-(2-hydroxynaphthalen-1...)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of Hsp90 in human SKBR3 cells assessed as Her2 degradation after 24 hrs by Western blotMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-beta(Homo sapiens (Human))
Vernalis (R&D)

LigandPNGBDBM15408(2,5-dichloro-N-[4-hydroxy-3-(2-hydroxynaphthalen-1...)
Affinity DataIC50:  700nMAssay Description:Binding affinity to Hsp90 by fluorescence polarization assayMore data for this Ligand-Target Pair