BDBM163433 BA-1049::US11198680, Compound BA 1049 (R)::US9687483, 1

SMILES C[C@@H](N)C1CCN(CC1)S(=O)(=O)c1cccc2cnccc12

InChI Key InChIKey=MGLIYKZFLDTAMW-GFCCVEGCSA-N

Data  9 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 163433   

TargetRho-associated protein kinase 2(Rattus norvegicus (Rat))
Bioaxone Biosciences

US Patent
LigandPNGBDBM163433(BA-1049 | US11198680, Compound BA 1049 (R) | US968...)
Affinity DataIC50:  1.60E+3nMT: 2°CAssay Description:The inhibitor potency of BA-1049 (racemic mixture) and Fasudil (Calbiochem) were compared by fluorescent polarization assays performed using a Biomek...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Rattus norvegicus (Rat))
Bioaxone Biosciences

US Patent
LigandPNGBDBM163433(BA-1049 | US11198680, Compound BA 1049 (R) | US968...)
Affinity DataIC50:  940nMT: 2°CAssay Description:The inhibitor potency of BA-1049 (racemic mixture) and Fasudil (Calbiochem) were compared by fluorescent polarization assays performed using a Biomek...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Rattus norvegicus (Rat))
Bioaxone Biosciences

US Patent
LigandPNGBDBM163433(BA-1049 | US11198680, Compound BA 1049 (R) | US968...)
Affinity DataIC50:  2.10E+4nMT: 2°CAssay Description:The inhibitor potency of BA-1049 (racemic mixture) and Fasudil (Calbiochem) were compared by fluorescent polarization assays performed using a Biomek...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Bioaxone Biosciences

US Patent
LigandPNGBDBM163433(BA-1049 | US11198680, Compound BA 1049 (R) | US968...)
Affinity DataIC50:  3.90E+3nMAssay Description:Compounds were tested using an 11-point curve with 3-fold serial dilutions. IC50 determinations were made using an ATP concentration of 10 uM. The hi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bioaxone Biosciences

US Patent
LigandPNGBDBM163433(BA-1049 | US11198680, Compound BA 1049 (R) | US968...)
Affinity DataIC50:  240nMAssay Description:Compounds were tested using an 11-point curve with 3-fold serial dilutions. IC50 determinations were made using an ATP concentration of 10 uM. The hi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bioaxone Biosciences

US Patent
LigandPNGBDBM163433(BA-1049 | US11198680, Compound BA 1049 (R) | US968...)
Affinity DataKd:  160nMAssay Description:Compounds were tested using an 11-point curve with 3-fold serial dilutions. IC50 determinations were made using an ATP concentration of 10 uM. The hi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bioaxone Biosciences

US Patent
LigandPNGBDBM163433(BA-1049 | US11198680, Compound BA 1049 (R) | US968...)
Affinity DataIC50:  340nMAssay Description:Compounds were tested using an 11-point curve with 3-fold serial dilutions. IC50 determinations were made using an ATP concentration of 15 uM. The hi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Bioaxone Biosciences

US Patent
LigandPNGBDBM163433(BA-1049 | US11198680, Compound BA 1049 (R) | US968...)
Affinity DataIC50:  2.96E+4nMAssay Description:Compounds were tested using an 11-point curve with 3-fold serial dilutions. IC50 determinations were made using an ATP concentration of 70 uM. The hi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bioaxone Biosciences

US Patent
LigandPNGBDBM163433(BA-1049 | US11198680, Compound BA 1049 (R) | US968...)
Affinity DataIC50:  340nMAssay Description:Compounds were tested using an 11-point curve with 3-fold serial dilutions. IC50 determinations were made using an ATP concentration of 15 uM. The hi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Bioaxone Biosciences

US Patent
LigandPNGBDBM163433(BA-1049 | US11198680, Compound BA 1049 (R) | US968...)
Affinity DataKd:  155nMAssay Description:Compounds were tested using an 11-point curve with 3-fold serial dilutions. IC50 determinations were made using an ATP concentration of 10 uM. The hi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Bioaxone Biosciences

US Patent
LigandPNGBDBM163433(BA-1049 | US11198680, Compound BA 1049 (R) | US968...)
Affinity DataIC50:  2.96E+4nMAssay Description:Compounds were tested using an 11-point curve with 3-fold serial dilutions. IC50 determinations were made using an ATP concentration of 70 uM. The hi...More data for this Ligand-Target Pair
In DepthDetails US Patent