BDBM180274 US9676721, 82 2-cyano-1-{[4-(1-propyl-1H-pyrazole-4-sulfonyl)phenyl]methyl}-3-(pyridin-4-yl)guanidine

SMILES CCCn1cc(cn1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1

InChI Key InChIKey=NLQARQBICKDLFP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 180274   

TargetNicotinamide phosphoribosyltransferase(Human)
Forma Tm

US Patent
LigandChemical structure of BindingDB Monomer ID 180274BDBM180274(US9676721, 82 2-cyano-1-{[4-(1-propyl-1H-pyrazole-...)
Affinity DataIC50: 4.10nMpH: 7.5 T: 2°CAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/16/2018
Entry Details
US Patent