BDBM189939 US10227346, Example 57::US10426135, Example 57::US9670201, 57 3-cyano-N-(3-(1-(cyclopentanecarbonyl)piperidin-4-yl)-1,4-dimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-5-(2-methoxyethoxy)benzamide::US9920054, Example 57

SMILES COCCOc1cc(cc(c1)C(=O)Nc1cnc2n(C)cc(C3CCN(CC3)C(=O)C3CCCC3)c2c1C)C#N

InChI Key InChIKey=PEWWXSFUUXSMIC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 189939   

TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 189939BDBM189939(US9670201, 57 3-cyano-N-(3-(1-(cyclopentanecarbony...)
Affinity DataIC50: 11.7nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 189939BDBM189939(US9670201, 57 3-cyano-N-(3-(1-(cyclopentanecarbony...)
Affinity DataIC50: 11.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2020
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 189939BDBM189939(US9670201, 57 3-cyano-N-(3-(1-(cyclopentanecarbony...)
Affinity DataIC50: 11.7nMAssay Description:The activity of compound of the invention can be determined by a co-activator recruitment by TR-FRET (time-resolved fluorescence resonance energy tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Pfizer

US Patent
LigandChemical structure of BindingDB Monomer ID 189939BDBM189939(US9670201, 57 3-cyano-N-(3-(1-(cyclopentanecarbony...)
Affinity DataIC50: 12nMpH: 7.5 T: 2°CAssay Description:Specifically, in one embodiment the aforementioned assay was performed as outlined below. The assay was carried out in black polystyrene, 384-well pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2018
Entry Details
US Patent