BDBM19412 CHEMBL235674::benzamide-type inhibitor, 4::pyridin-3-ylmethyl N-[(4-{[2-amino-5-(thiophen-2-yl)phenyl]carbamoyl}phenyl)methyl]carbamate

SMILES Nc1ccc(cc1NC(=O)c1ccc(CNC(=O)OCc2cccnc2)cc1)-c1cccs1

InChI Key InChIKey=ASIJNKHQTPQFCQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 19412   

TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19412(CHEMBL235674 | benzamide-type inhibitor, 4 | pyrid...)
Affinity DataIC50:  20nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19412(CHEMBL235674 | benzamide-type inhibitor, 4 | pyrid...)
Affinity DataIC50:  100nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19412(CHEMBL235674 | benzamide-type inhibitor, 4 | pyrid...)
Affinity DataIC50:  190nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19412(CHEMBL235674 | benzamide-type inhibitor, 4 | pyrid...)
Affinity DataIC50:  2.77E+4nMAssay Description:Inhibition of HDAC3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19412(CHEMBL235674 | benzamide-type inhibitor, 4 | pyrid...)
Affinity DataIC50:  3.17E+4nMAssay Description:Inhibition of HDAC8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19412(CHEMBL235674 | benzamide-type inhibitor, 4 | pyrid...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of HDAC6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19412(CHEMBL235674 | benzamide-type inhibitor, 4 | pyrid...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM19412(CHEMBL235674 | benzamide-type inhibitor, 4 | pyrid...)
Affinity DataIC50:  6nMAssay Description:Inhibition of HDAC2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed