BDBM21400 CHEMBL192571::N-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene)sulfonyl]-4-(4,4-dimethylpiperidin-1-yl)benzamide::Phenylpiperidine, 1a
SMILES CN(C)CC[C@H](CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCC(C)(C)CC1
InChI Key InChIKey=DWEHITNKTMMZBR-RUZDIDTESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 21400
Affinity DataKi: 0.800nMAssay Description:Binding affinity to Bcl-XL by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nMAssay Description:Binding affinity to Bcl-xlMore data for this Ligand-Target Pair
Affinity DataKi: 0.800nM ΔG°: -12.4kcal/mole EC50: 470nMpH: 7.4 T: 2°CAssay Description:The binding affinities (Ki) of compounds were determined using fluorescence polarization assays (FPA) that measure their ability to competitively dis...More data for this Ligand-Target Pair
Affinity DataKi: 6.30nMAssay Description:Displacement of BODIPY-Bak conjugated peptide from GST-tagged human Wild type Bcl-2-like protein 1 expressed in Escherichia coli BL21 cells at 10 uM ...More data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataKi: 62nMAssay Description:Binding affinity to BCl2More data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataKi: 67nM EC50: 2.20E+3nMAssay Description:The binding affinities (Ki) of compounds were determined using fluorescence polarization assays (FPA) that measure their ability to competitively dis...More data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataKi: 67nMAssay Description:Binding affinity to Bcl2 by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: 360nMAssay Description:Binding affinity to Bcl-XL in 1% human serum by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity for GST-tagged human BCL2A1 expressed in Escherichia coli BL21 cellsMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 homolog(Mus musculus (Mouse))
University Of Washington
Curated by ChEMBL
University Of Washington
Curated by ChEMBL
Affinity DataKd: >1.00E+3nMAssay Description:Binding affinity for GST-tagged mouse MCL1 expressed in Escherichia coli BL21 cellsMore data for this Ligand-Target Pair
Affinity DataKd: 1.36E+4nMAssay Description:Binding affinity for human serum albumin domain IIIMore data for this Ligand-Target Pair
Affinity DataEC50: 470nMAssay Description:Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of gelatinMore data for this Ligand-Target Pair
Affinity DataKd: 459nMAssay Description:Binding affinity to BclwMore data for this Ligand-Target Pair
Affinity DataEC50: 5.10E+3nMAssay Description:Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of 3% fetal bovine serumMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Abbott Laboratories
Curated by ChEMBL
Abbott Laboratories
Curated by ChEMBL
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to Mcl1More data for this Ligand-Target Pair