BDBM242420 US10047093, 8-105::US10392392, Example 8-105::US10875864, EX. 8-105::US9416132, 8-105

SMILES FC(F)(F)Oc1cccc(c1)-c1nnc2ccc(N[C@@H]3CC[C@H](Br)CC3)cn12

InChI Key InChIKey=OMLIXNDNKDQSNH-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 242420   

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 242420BDBM242420(US10047093, 8-105 | US9416132, 8-105 | US10392392,...)
Affinity DataIC50: 2.49E+3nMT: 2°CAssay Description:These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 242420BDBM242420(US10047093, 8-105 | US9416132, 8-105 | US10392392,...)
Affinity DataIC50: 2.49E+3nMT: 2°CAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 242420BDBM242420(US10047093, 8-105 | US9416132, 8-105 | US10392392,...)
Affinity DataIC50: 2.49E+3nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 242420BDBM242420(US10047093, 8-105 | US9416132, 8-105 | US10392392,...)
Affinity DataIC50: 2.49E+3nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
US Patent