BDBM267349 3-chloro-5-((1-((6- (4-(2,2-difluoro-1- hydroxyethyl)phenyl)- 3-oxo-2,3- dihydropyridazin-4- yl)methyl)-6-oxo-4- (trifluoromethyl)- 1,6- dihydropyrimidin- 5- yl)oxy)benzonitrile::US10189831, Example 125::US9718819, 125

SMILES OC(C(F)F)c1ccc(cc1)-c1cc(Cn2cnc(c(Oc3cc(Cl)cc(c3)C#N)c2=O)C(F)(F)F)c(=O)[nH]n1

InChI Key InChIKey=WKRNXQCMBPCQTA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 267349   

TargetGag-Pol polyprotein(HIV-1)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 267349BDBM267349(3-chloro-5-((1-((6- (4-(2,2-difluoro-1- hydroxyeth...)
Affinity DataIC50: 8nMpH: 7.8 T: 2°CAssay Description:The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2018
Entry Details
US Patent

TargetGag-Pol polyprotein(HIV-1)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 267349BDBM267349(3-chloro-5-((1-((6- (4-(2,2-difluoro-1- hydroxyeth...)
Affinity DataIC50: 8nMAssay Description:The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details
US Patent