BDBM267367 3-((1-((2-amino-6-oxo- 1,6-dihydropyrimidin-5- yl)methyl)-6-oxo-4- (trifluoromethyl)-1,6- dihydropyrimidin-5- yl)oxy)-5- chlorobenzonitrile::US10189831, Example 143::US9718819, 143

SMILES N#Cc1cc(Cl)cc(Oc2c(C(F)(F)F)ncn(Cc3cnc(N)[nH]c3=O)c2=O)c1

InChI Key InChIKey=JCENYBJYLAEADZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 267367   

TargetGag-Pol polyprotein(HIV-1)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 267367BDBM267367(3-((1-((2-amino-6-oxo- 1,6-dihydropyrimidin-5- yl)...)
Affinity DataIC50: 7nMAssay Description:The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details
US Patent

TargetGag-Pol polyprotein(HIV-1)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 267367BDBM267367(3-((1-((2-amino-6-oxo- 1,6-dihydropyrimidin-5- yl)...)
Affinity DataIC50: 7nMpH: 7.8 T: 2°CAssay Description:The heterodimeric nucleic acid substrate used in the HIV-1 RT polymerase reactions was generated by annealing the DNA primer, biotinylated pD500 (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2018
Entry Details
US Patent