BDBM269327 2-(2-fluoro-4-(6-fluoronaphthalen-2-yl)phenyl)-4,4-dimethyl-1-((1-(1-methylcyclopropanecarbonyl)azetidin-3-yl)methyl)-1H-imidazol-5(4H)-one ::US10413545, Compound 72::US9718813, Compound 72

SMILES CC1(CC1)C(=O)N1CC(CN2C(=O)C(C)(C)N=C2c2ccc(cc2F)-c2ccc3cc(F)ccc3c2)C1

InChI Key InChIKey=UDVYJDDXFMTKLM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 269327   

TargetFatty acid synthase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269327(2-(2-fluoro-4-(6-fluoronaphthalen-2-yl)phenyl)-4,4...)
Affinity DataIC50:  35.5nMpH: 7.5 T: 2°CAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269327(2-(2-fluoro-4-(6-fluoronaphthalen-2-yl)phenyl)-4,4...)
Affinity DataIC50:  35.5nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target1,5-anhydro-D-fructose reductase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269327(2-(2-fluoro-4-(6-fluoronaphthalen-2-yl)phenyl)-4,4...)
Affinity DataIC50:  58.9nMpH: 7.5 T: 2°CAssay Description:10 μL assay buffer (100 mM KH2PO4 pH 7.5) was added to a 384-well clear plate (costar 3702). 0.3 μL compound (at concentrations of 30 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent