BDBM269484 US10058534, 139
SMILES CC(F)(F)c1cc(F)ccc1-c1sc2cc(O)ccc2c1Oc1ccc(\C=C\C(O)=O)cc1
InChI Key InChIKey=SJXNPGGVGZXKKI-NYYWCZLTSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 269484
Affinity DataIC50: 6.10nMpH: 5.1 T: 2°CAssay Description:The ER transcription assay is a reporter assay that is based on the ability of ER to induce transcription from a luciferase reporter gene containing ...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 0.200nMpH: 7.4 T: 2°CAssay Description:Plate MCF7 cells at 0.3 million cells/mL (100 l/well) in black, clear-bottom 96-well plates (Greiner, catalog number 655090) in DMEM/F12 media (Gibco...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Induction of selective estrogen receptor alpha degradation in human MCF7 cells harboring TK-ERE-Luc assessed as reduction in estradiol-induced transc...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Induction of selective estrogen receptor alpha degradation in human MCF7 cells after 18 to 24 hrs by in-cell Western analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 8.90nMAssay Description:Induction of selective estrogen receptor alpha degradation in human MCF7 cells harboring TK-ERE-Luc assessed as reduction in estradiol-induced GREB1 ...More data for this Ligand-Target Pair