BDBM271287 US10059720, Example 102::US10975091, Example 102

SMILES N[C@@H](COc1ccc(F)cc1)[C@](O)(Cc1cc(ccn1)N(CC(F)(F)F)C1CCCCC1)C(O)=O

InChI Key InChIKey=HICGSPGBFOKSBT-JTHBVZDNSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 271287   

TargetLeucyl-cystinyl aminopeptidase(Rat)
Astellas Pharma

US Patent
LigandPNGBDBM271287(US10059720, Example 102 | US10975091, Example 102)
Affinity DataIC50:  6.5nMAssay Description:Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetLeucyl-cystinyl aminopeptidase(Human)
Astellas Pharma

US Patent
LigandPNGBDBM271287(US10059720, Example 102 | US10975091, Example 102)
Affinity DataIC50:  7.20nMAssay Description:hP-LAP: HEK293 cells forced to transiently express hP-LAP were prepared by lipofection, homogenized, and then subjected to ultracentrifugation at 100...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetLeucyl-cystinyl aminopeptidase(Rat)
Astellas Pharma

US Patent
LigandPNGBDBM271287(US10059720, Example 102 | US10975091, Example 102)
Affinity DataIC50:  6.5nMAssay Description:IRAP: Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetLeucyl-cystinyl aminopeptidase(Human)
Astellas Pharma

US Patent
LigandPNGBDBM271287(US10059720, Example 102 | US10975091, Example 102)
Affinity DataIC50:  7.20nMAssay Description:HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent