BDBM273081 (R)-1-(5,6-dimethyl-7-oxo-6,7-dihydro-[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-N-(2-methylbenzyl)pyrrolidine-2-carboxamide::US10065972, Example 229

SMILES Cc1ccccc1CNC(=O)[C@H]1CCCN1c1nc2c(nc(C)n(C)c2=O)s1

InChI Key InChIKey=MPVKKSLILLGEGY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273081   

TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Human)
Mitsubishi Tanabe Pharma

US Patent
LigandChemical structure of BindingDB Monomer ID 273081BDBM273081((R)-1-(5,6-dimethyl-7-oxo-6,7-dihydro-[1,3]thiazol...)
Affinity DataIC50: 21nMpH: 8.0Assay Description:The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent