BDBM273163 (R)-N-benzyl-1-(7-cyclopropyl-5-ethyl-4-oxo-4,5-dihydro[1,3]thiazolo[4,5-d]pyridazin-2-yl)pyrrolidine-2-carboxamide::US10065972, Example 614

SMILES CCn1nc(C2CC2)c2sc(nc2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1

InChI Key InChIKey=LAUQAQJIHUNERI-MRXNPFEDSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273163   

TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM273163((R)-N-benzyl-1-(7-cyclopropyl-5-ethyl-4-oxo-4,5-di...)
Affinity DataIC50:  16nMpH: 8.0Assay Description:The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent