BDBM274700 N-(6-(1-benzyl-4-(4-fluorophenyl)-1H- imidazol-5-yl)imidazo[1,2-b]pyridazin-2- yl)pivalamide::US9556179, Compound 275

SMILES CC(C)(C)C(=O)Nc1cn2nc(ccc2n1)-c1c(ncn1Cc1ccccc1)-c1ccc(F)cc1

InChI Key InChIKey=LKKOZCRQMMCWBJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274700   

TargetCasein kinase I isoform delta(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 274700BDBM274700(N-(6-(1-benzyl-4-(4-fluorophenyl)-1H- imidazol-5-y...)
Affinity DataIC50: 0.545nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetCasein kinase I isoform epsilon(Human)
Bristol Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 274700BDBM274700(N-(6-(1-benzyl-4-(4-fluorophenyl)-1H- imidazol-5-y...)
Affinity DataIC50: 4.23nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent