BDBM274711 N-(6-(1-(2,2-difluoroethyl)-2-ethyl- 4-(4-fluorophenyl)-1H-imidazol-5- yl)imidazo[1,2-b]pyridazin-2-yl)- 2-fluoroisonicotinamide::US9556179, Compound 286

SMILES FC(F)Cn1c(nc(c1-c1ccc2nc(NC(=O)c3ccnc(F)c3)cn2n1)-c1ccc(F)cc1)C1CC1

InChI Key InChIKey=MJUVBTIVBBNSHY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 274711   

TargetCasein kinase I isoform delta(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 274711BDBM274711(N-(6-(1-(2,2-difluoroethyl)-2-ethyl- 4-(4-fluoroph...)
Affinity DataIC50: 0.727nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent

TargetCasein kinase I isoform epsilon(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 274711BDBM274711(N-(6-(1-(2,2-difluoroethyl)-2-ethyl- 4-(4-fluoroph...)
Affinity DataIC50: 6.78nMpH: 7.4 T: 2°CAssay Description:The kinase assay was performed in V-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme, subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2018
Entry Details
US Patent