BDBM275810 1-(N-(5-chloro-4-((5- chloro-6-isobutoxy- pyridin-3-yl)oxy)- 2-fluorobenzoyl) sulfamoyl)piperidine- 4-carboxylate::US10071957, Example 27

SMILES COC(=O)C1CCN(CC1)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(OCC(C)C)c(Cl)c2)cc1F

InChI Key InChIKey=ASJCGOXQSWSMNW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 275810   

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 275810BDBM275810(1-(N-(5-chloro-4-((5- chloro-6-isobutoxy- pyridin-...)
Affinity DataIC50: 218nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 275810BDBM275810(1-(N-(5-chloro-4-((5- chloro-6-isobutoxy- pyridin-...)
Affinity DataIC50: 1.59E+3nMpH: 7.4 T: 2°CAssay Description:Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2018
Entry Details
US Patent