BDBM278758 2-(2,5- diazabicyclo[2.2.2]oct- 2-yl)-N-[4- (difluoromethyl)thiophen- 3-yl]pyrrolo[1,2- b]pyridazine-7- carboxamide trifluoroacetate::US10040798, Example 56

SMILES FC(F)c1cscc1NC(=O)c1ccc2ccc(nn12)N1CC2CCC1CN2

InChI Key InChIKey=MIPXSZYVYNEGRT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 278758   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 278758BDBM278758(2-(2,5- diazabicyclo[2.2.2]oct- 2-yl)-N-[4- (diflu...)
Affinity DataIC50: 95nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2018
Entry Details
US Patent