BDBM280355 4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyridyl]amino]-N-[2-hydroxy-1-(hydroxymethyl)ethyl]pyridine-3-carboxamide::US10030004, Compound 22::US10501436, Compound 22::US11053216, Compound 22::US11702401, Compound 22

SMILES CC(C)c1cnc(cc1Nc1ccncc1C(=O)NC(CO)CO)-c1cc(Cl)ccc1F

InChI Key InChIKey=IPBLCOKXDQHSQW-UHFFFAOYSA-N

Data  24 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 280355   

TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  7.29E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetTGF-beta receptor type-1(Homo sapiens (Human))TBA

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  24nMAssay Description:Inhibitory activity against Escherichia coli leader peptidase using substrate AMore data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  56.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetTGF-beta receptor type-1(Homo sapiens (Human))TBA

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  24.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1B(Mus musculus (Mouse))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  7.29E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  56.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetTGF-beta receptor type-1(Homo sapiens (Human))TBA

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  24.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
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TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  7.29E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMMore data for this Ligand-Target Pair

Target InfoPDBKEGG
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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  56.7nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetTGF-beta receptor type-1(Homo sapiens (Human))TBA

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  24.7nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
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TargetBone morphogenetic protein 10(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMMore data for this Ligand-Target Pair

Target InfoPDB
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GoogleScholar

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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  7.29E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  56.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetTGF-beta receptor type-1(Homo sapiens (Human))TBA

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  24.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathway
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TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDB
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TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Antagonist effect against bradykinin B2 receptor was determined in rabbit jugular veinMore data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:pA2 for inhibition of NPY-stimulated [Ca2+] mobilization in HEL cellsMore data for this Ligand-Target Pair

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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  57nMAssay Description:Inhibitory activity against Escherichia coli leader peptidase using substrate AMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Inhibitory activity against Escherichia coli leader peptidase using substrate AMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50:  7.29E+3nMAssay Description:Inhibitory activity against Escherichia coli leader peptidase using substrate AMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280355(4-[[2-(5-chloro-2-fluoro-phenyl)-5-isopropyl-4-pyr...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+6nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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