BDBM283569 N-((6-amino-2-methylpyridin-3-yl)methyl)-2- ((8-amino-3-chloroquinolin-6- yl)methyl)isonicotinamide::US10023557, Example 218::US10308637, Example 218

SMILES Cc1nc(N)ccc1CNC(=O)c1ccnc(Cc2cc(N)c3ncc(Cl)cc3c2)c1

InChI Key InChIKey=NONJMWYIKSDSMU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 283569   

TargetPlasma kallikrein(Human)
Lifesci Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 283569BDBM283569(US10023557, Example 218 | N-((6-amino-2-methylpyri...)
Affinity DataIC50: 100nMpH: 7.5Assay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Lifesci Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 283569BDBM283569(US10023557, Example 218 | N-((6-amino-2-methylpyri...)
Affinity DataIC50: 100nMAssay Description:A 10 mM solution of the test compound was made in DMSO. This solution was serially diluted 1:5 in DMSO to yield 2000, 400, 80, 16, 3.2, 0.64, 0.128, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent