BDBM285434 2-methyl-4-[5-(methylsulfonylmethyl)-2- (2,2,2-trifluoroethoxy)phenyl] isoquinolin-1-one::US10023592, Example 488

SMILES Cn1cc(-c2cc(CS(C)(=O)=O)ccc2OCC(F)(F)F)c2ccccc2c1=O

InChI Key InChIKey=INXNDKZZPZLIDT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 285434   

TargetBromodomain-containing protein 4(Human)
Celgene Quanticel Research

US Patent
LigandChemical structure of BindingDB Monomer ID 285434BDBM285434(US10023592, Example 488 | 2-methyl-4-[5-(methylsul...)
Affinity DataIC50: 500nMpH: 7.3Assay Description:Determination of the IC50 for the heterocyclic derivative BRD4 inhibitors disclosed herein was performed as follows. His-tagged BRD4 was cloned, expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2019
Entry Details
US Patent