BDBM285571 3-(4-chloro-3-fluorophenyl)-N-(2,2-difluorocyclopro-pyl)imidazo[1,2-b]pyridazine-2-carboxamide::US10077269, Example 44::US10669279, Example 44::US9598421, Example 44

SMILES Fc1cc(ccc1Cl)-c1c(nc2cccnn12)C(=O)NC1CC1(F)F

InChI Key InChIKey=LLYJCFVFPOZAJN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 285571   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736,S654A](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285571(3-(4-chloro-3-fluorophenyl)-N-(2,2-difluorocyclopr...)
Affinity DataIC50:  3.92nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM285571(3-(4-chloro-3-fluorophenyl)-N-(2,2-difluorocyclopr...)
Affinity DataIC50:  320nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285571(3-(4-chloro-3-fluorophenyl)-N-(2,2-difluorocyclopr...)
Affinity DataIC50:  320nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285571(3-(4-chloro-3-fluorophenyl)-N-(2,2-difluorocyclopr...)
Affinity DataIC50:  320nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285571(3-(4-chloro-3-fluorophenyl)-N-(2,2-difluorocyclopr...)
Affinity DataIC50:  3.92nMAssay Description:Human PDE4A3 coding sequence (amino acids 2 to 825 from the sequence with accession number NP_001104779) was cloned into the baculovirus expression v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM285571(3-(4-chloro-3-fluorophenyl)-N-(2,2-difluorocyclopr...)
Affinity DataIC50:  3.92nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent