BDBM295037 US10112926, Example 4.5::trans 3-(6-Amino-5-(2- methyl-2H-1,2,3-triazol- 4-yl)pyridin-3-yl)-N-(4- hydroxy cyclohexyl)-4- methylbenzene sulfonamide hydrochloride

SMILES Cc1ccc(S(=O)(=O)N[C@H]2CC[C@H](O)CC2)cc1-c1cnc(N)c(-c2cnn(C)n2)c1

InChI Key InChIKey=MTNQTVCKFYRZKH-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 295037   

LigandChemical structure of BindingDB Monomer ID 295037BDBM295037(trans 3-(6-Amino-5-(2- methyl-2H-1,2,3-triazol- 4-...)
Affinity DataIC50: 250nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 295037BDBM295037(trans 3-(6-Amino-5-(2- methyl-2H-1,2,3-triazol- 4-...)
Affinity DataIC50: 480nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 295037BDBM295037(trans 3-(6-Amino-5-(2- methyl-2H-1,2,3-triazol- 4-...)
Affinity DataIC50: 575nMpH: 7.5Assay Description:The TR-FRET Adapta Universal Kinase Assay Kit was purchased from Invitrogen Corporation (Carlsbad, Calif., USA) (Cat. No. PV5099). The kit contains t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 295037BDBM295037(trans 3-(6-Amino-5-(2- methyl-2H-1,2,3-triazol- 4-...)
Affinity DataIC50: 2.80E+3nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetPhosphatidylinositol 4-kinase beta(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 295037BDBM295037(trans 3-(6-Amino-5-(2- methyl-2H-1,2,3-triazol- 4-...)
Affinity DataIC50: 5.25E+3nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 295037BDBM295037(trans 3-(6-Amino-5-(2- methyl-2H-1,2,3-triazol- 4-...)
Affinity DataIC50: 1.00E+4nMpH: 7.5Assay Description:Binding Assays are based on the binding and displacement of an Alexa Fluor 647-labeled, ATP-competitive kinase inhibitors to the kinase of interest. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 295037BDBM295037(trans 3-(6-Amino-5-(2- methyl-2H-1,2,3-triazol- 4-...)
Affinity DataIC50: 1.00E+4nMpH: 7.5 T: 2°CAssay Description:The luminescence-based ATP detection reagent KinaseGlo was obtained from Promega, (Cat. No. V6714, Lot No. 236161) through Catalys, Wallisellen, Swit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2019
Entry Details
US Patent