BDBM295872 N-(4-Chloro-1H-indazol-5-yl)-5-(3-(1-(2-methoxyethyl)-1H-imidazol-2-yl)phenyl)-1,3,4-thiadiazol-2-amine 2,2,2-trifluoroacetic Acid::US10112935, Example 44

SMILES COCCn1ccnc1-c1cccc(-c2nnc(Nc3ccc4[nH]ncc4c3Cl)s2)c1

InChI Key InChIKey=CNSONDGNUCJGPV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 295872   

TargetRho-associated protein kinase 1(Human)
Lycera

US Patent
LigandChemical structure of BindingDB Monomer ID 295872BDBM295872(US10112935, Example 44 | N-(4-Chloro-1H-indazol-5-...)
Affinity DataIC50: 1.00E+3nMT: 2°CAssay Description:Assays for ROCK inhibition were performed using the following protein constructs: glutathione S-transferase (GST)-tagged human ROCK1 catalytic domain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Lycera

US Patent
LigandChemical structure of BindingDB Monomer ID 295872BDBM295872(US10112935, Example 44 | N-(4-Chloro-1H-indazol-5-...)
Affinity DataIC50: 1.00E+3nMT: 2°CAssay Description:Assays for ROCK inhibition were performed using the following protein constructs: glutathione S-transferase (GST)-tagged human ROCK1 catalytic domain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent