BDBM295981 4-{2-methoxy-4- [2-(4-methyl- phenyl) pyrrolidine- 1-carbonyl] phenyl}-1H- pyrazole::US10112939, Example 23

SMILES COc1cc(ccc1-c1cn[nH]c1)C(=O)N1CCCC1c1ccc(C)cc1

InChI Key InChIKey=HOTPINNOTWIGJF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 295981   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandChemical structure of BindingDB Monomer ID 295981BDBM295981(US10112939, Example 23 | 4-{2-methoxy-4- [2-(4-met...)
Affinity DataIC50: 215nMpH: 7.5Assay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2019
Entry Details
US Patent