BDBM312063 N-(3-Carbamoyl-1-methyl-1H-pyrazol-4-yl)-5-(3-oxopiperazin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide::US9649308, Example 38

SMILES Cn1cc(NC(=O)c2cnn3ccc(nc23)N2CCNC(=O)C2)c(n1)C(N)=O

InChI Key InChIKey=OCMVSUGPLBMBPJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 312063   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 312063BDBM312063(US9649308, Example 38 | N-(3-Carbamoyl-1-methyl-1H...)
Affinity DataIC50: 400nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2019
Entry Details
US Patent