BDBM320231 3-{[(5R)-3-methyl-2- oxo-1,3-oxazolidin- 5-yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[2- (trifluoromethyl) pyrimidin-5- yl]ethyl}benzamide::US10174016, Example 398::US10202369, Example 398::US10472354, Example 398

SMILES C[C@@H](NC(=O)c1cc(OC[C@H]2CN(C)C(=O)O2)cc(c1)-c1ncc(C)s1)c1cnc(nc1)C(F)(F)F

InChI Key InChIKey=OAEQMLBAMDEFGR-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 320231   

TargetP2X purinoceptor 3(Human)
Bayer Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 320231BDBM320231(3-{[(5R)-3-methyl-2- oxo-1,3-oxazolidin- 5-yl]meth...)
Affinity DataIC50: 17nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
US Patent

TargetP2X purinoceptor 3(Human)
Bayer Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 320231BDBM320231(3-{[(5R)-3-methyl-2- oxo-1,3-oxazolidin- 5-yl]meth...)
Affinity DataIC50: 17nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetP2X purinoceptor 3(Human)
Bayer Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 320231BDBM320231(3-{[(5R)-3-methyl-2- oxo-1,3-oxazolidin- 5-yl]meth...)
Affinity DataIC50: 17nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2020
Entry Details
US Patent

TargetP2X purinoceptor 3(Human)
Bayer Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 320231BDBM320231(3-{[(5R)-3-methyl-2- oxo-1,3-oxazolidin- 5-yl]meth...)
Affinity DataIC50: 17nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetP2X purinoceptor 2/3(Human)
Bayer Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 320231BDBM320231(3-{[(5R)-3-methyl-2- oxo-1,3-oxazolidin- 5-yl]meth...)
Affinity DataIC50: 1.80E+3nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
US Patent

TargetP2X purinoceptor 2(Human)
Beyer Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 320231BDBM320231(3-{[(5R)-3-methyl-2- oxo-1,3-oxazolidin- 5-yl]meth...)
Affinity DataIC50: 1.80E+3nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetP2X purinoceptor 2(Human)
Beyer Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 320231BDBM320231(3-{[(5R)-3-methyl-2- oxo-1,3-oxazolidin- 5-yl]meth...)
Affinity DataIC50: 1.80E+3nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetP2X purinoceptor 2/3(Human)
Bayer Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 320231BDBM320231(3-{[(5R)-3-methyl-2- oxo-1,3-oxazolidin- 5-yl]meth...)
Affinity DataIC50: 1.80E+3nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2020
Entry Details
US Patent