BDBM345428 1-[1-(4-isopropylphenyl)sulfonyl-4,5-dihydroimidazol-2-yl]-4-(4-methylcyclohexyl)piperazine::US10202354, Example 93

SMILES CC1CCC(N2CCN(C3=NCCN3S(=O)(=O)c3ccc(C(C)C)cc3)CC2)CC1

InChI Key InChIKey=PPAQPYQSNAUUJQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 345428   

TargetLysine-specific demethylase 2B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 345428BDBM345428(1-[1-(4-isopropylphenyl)sulfonyl-4,5-dihydroimidaz...)
Affinity DataIC50: 2.26nMAssay Description:Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
US Patent