BDBM349498 1-methyl-4-[(4R)-4-methyl-2-oxo-1,3,4,5-tetrahydro-1,5-benzodiazepin-6-yl]-7-(1-methylpyrazol-4-yl)-2,3-dihydroquinoxaline-6-carbonitrile::US10206931, Example 306

SMILES CN\C=C(/C=N)c1cc2N(C)CCN(c3cccc4NC(=O)C[C@@H](C)Nc34)c2cc1C#N

InChI Key InChIKey=CXDDRMUOLXEPGY-AAJMVYRGSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 349498   

TargetBromodomain-containing protein 4 [42-168](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM349498(1-methyl-4-[(4R)-4-methyl-2-oxo-1,3,4,5-tetrahydro...)
Affinity DataIC50:  4.36E+3nMAssay Description:His/Flag epitope tagged BRD4 BD142-168 was cloned, expressed, and purified to. BRD4 binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCREB-binding protein(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM349498(1-methyl-4-[(4R)-4-methyl-2-oxo-1,3,4,5-tetrahydro...)
Affinity DataIC50:  3nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent