BDBM354288 3-((4-((4-(3-(3-(tert-Butyl)-1-(3-(dimethylphosphoryl)phenyl)-1H-pyrazol-5-yl)ureido)-naphthalen-1-yl)oxy)pyrimidin-2-yl)amino)-N-(2-morpholinoethyl)benzamide::US9796742, Example 16

SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cccc(c4)C(=O)NCCN4CCOCC4)n3)c3ccccc23)n(n1)-c1cccc(c1)P(C)(C)=O

InChI Key InChIKey=DZGVCEXUTQKUFD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 354288   

TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandChemical structure of BindingDB Monomer ID 354288BDBM354288(3-((4-((4-(3-(3-(tert-Butyl)-1-(3-(dimethylphospho...)
Affinity DataIC50: 72nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3 enzyme isoform (Invitrogen), are evaluated by determining the level of acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
US Patent