BDBM354786 6-(2,3- dihydrobenzo[b][1,4]dioxin- 6-yl)-1-(1H-indol-5-yl)-1H- imidazo[4,5-b]pyrazin- 2(3H)-one::US10485800, Example 63::US9814704, Example 63

SMILES O=c1[nH]c2ncc(nc2n1-c1ccc2[nH]ccc2c1)-c1ccc2OCCOc2c1

InChI Key InChIKey=IRYXPYKCDKUXHO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354786   

TargetMitogen-activated protein kinase kinase kinase 11(Human)
The University of Rochester

US Patent
LigandChemical structure of BindingDB Monomer ID 354786BDBM354786(US9814704, Example 63 | 6-(2,3- dihydrobenzo[b][1,...)
Affinity DataIC50: 550nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
The University of Rochester

US Patent
LigandChemical structure of BindingDB Monomer ID 354786BDBM354786(US9814704, Example 63 | 6-(2,3- dihydrobenzo[b][1,...)
Affinity DataIC50: 550nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
US Patent