BDBM359507 4-[1-({2- chloro-6-[1- (trifluoro- methyl) cyclopropyl] phenyl} carbonyl)- 1,4,5,7- tetrahydro- pyrano[3,4-c] pyrazol- 3-yl]-3- fluorobenzoic acid::US10221142, Example 9B

SMILES OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C3(CC3)C(F)(F)F)c3COCCc23)c(F)c1

InChI Key InChIKey=LBCNWFXGWNHOMQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 359507   

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 359507BDBM359507(4-[1-({2- chloro-6-[1- (trifluoro- methyl) cyclopr...)
Affinity DataIC50: 3.5nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
US Patent