BDBM365054 (R)-9-isobutyl-6,8-dimethyl- 4-(2-((1-methyl-1H-pyrazol- 5-yl)amino)pyrimidin-4-yl)- 8,9-dihydro-1,2,2a1,6,8- pentaazabenzo[cd]azulen- 7(6H)-one::US10278975, Compound I-19::US10517878, Compound I-19::US10842799, I-19::US11376260, Example I-19::US9867833, Compound I-19

SMILES CC(C)C[C@H]1N(C)C(=O)N(C)c2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1

InChI Key InChIKey=JFELDSBZJTUBGV-MRXNPFEDSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 365054   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365054((R)-9-isobutyl-6,8-dimethyl- 4-(2-((1-methyl-1H-py...)
Affinity DataIC50:  1.15nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365054((R)-9-isobutyl-6,8-dimethyl- 4-(2-((1-methyl-1H-py...)
Affinity DataIC50:  1.15nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 6(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365054((R)-9-isobutyl-6,8-dimethyl- 4-(2-((1-methyl-1H-py...)
Affinity DataIC50:  1.15nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365054((R)-9-isobutyl-6,8-dimethyl- 4-(2-((1-methyl-1H-py...)
Affinity DataIC50:  1.15nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365054((R)-9-isobutyl-6,8-dimethyl- 4-(2-((1-methyl-1H-py...)
Affinity DataIC50:  1.15nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent