BDBM365093 4-(3-(4-fluorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1 - triazaacenaphthylen-7-yl)-N- (1-methyl-1H-pyrazol-5- yl)pyrimidin-2-amine::US10517878, Compound I-44::US10842799, I-44::US9867833, Compound I-44(S)

SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCC(Cc3ccc(F)cc3)c3nnc(c1)n23

InChI Key InChIKey=LKPURUXMGAYBBU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365093   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365093(4-(3-(4-fluorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1 -...)
Affinity DataIC50:  5nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365093(4-(3-(4-fluorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1 -...)
Affinity DataIC50: <0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365093(4-(3-(4-fluorobenzyl)-3,4- dihydro-5-oxa-1,2,2a1 -...)
Affinity DataIC50: <0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent