BDBM365164 4-(3-(3-chloro-4- fluorobenzyl)-3,4-dihydro-5 oxa-1,2,2a1- triazaacenaphthylen-7-yl)-N- (1-methyl-1H-pyrazol-5- yl)pyridin-2-amine::US10278975, Compound I-83::US10517878, Compound I-83::US10842799, I-83::US11376260, Example I-83::US9867833, Compound I-83

SMILES Cn1nccc1Nc1cc(ccn1)-c1cc2OCC(Cc3ccc(F)c(Cl)c3)c3nnc(c1)n23

InChI Key InChIKey=FYADUHPIKKDIKA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 365164   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365164(4-(3-(3-chloro-4- fluorobenzyl)-3,4-dihydro-5 oxa-...)
Affinity DataIC50:  0.111nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365164(4-(3-(3-chloro-4- fluorobenzyl)-3,4-dihydro-5 oxa-...)
Affinity DataIC50:  0.111nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 6(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365164(4-(3-(3-chloro-4- fluorobenzyl)-3,4-dihydro-5 oxa-...)
Affinity DataIC50:  0.111nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365164(4-(3-(3-chloro-4- fluorobenzyl)-3,4-dihydro-5 oxa-...)
Affinity DataIC50:  0.111nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365164(4-(3-(3-chloro-4- fluorobenzyl)-3,4-dihydro-5 oxa-...)
Affinity DataIC50:  0.111nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent