BDBM365182 N-(1-methyl-1H-pyrazol-5- yl)-4-(9-((1-methyl-1H- pyrazol-5-yl)methyl)-8,9- dihydro-7H-6-oxa- 1,2,2a1- triazabenzo[cd]azulen-4- yl)pyrimidin-2-amine::US10517878, Compound I-92::US10842799, I-92::US9867833, Compound I-92(S)

SMILES Cn1nccc1CC1CCOc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1

InChI Key InChIKey=QYSHIMJMAKJWLP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365182   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365182(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-((1-methyl-1H- ...)
Affinity DataIC50:  0.0850nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365182(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-((1-methyl-1H- ...)
Affinity DataIC50:  2.42nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365182(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-((1-methyl-1H- ...)
Affinity DataIC50:  2.42nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent