BDBM365196 N-(1-methyl-1H-pyrazol-5- yl)-4-(9-(3,3,3- trifluoropropyl)-8,9-dihydro- 7H-6-oxa-1,2,2a1- triazabenzo[cd]azulen-4- yl)pyrimidin-2-amine::US10517878, Compound I-102::US10842799, I-102::US9867833, Compound I-102(S)

SMILES Cn1nccc1Nc1nccc(n1)-c1cc2OCCC(CCC(F)(F)F)c3nnc(c1)n23

InChI Key InChIKey=IZZPDFMHVSTMKH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365196   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365196(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-(3,3,3- trifluo...)
Affinity DataIC50:  0.0250nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365196(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-(3,3,3- trifluo...)
Affinity DataIC50:  1.70nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365196(N-(1-methyl-1H-pyrazol-5- yl)-4-(9-(3,3,3- trifluo...)
Affinity DataIC50:  1.70nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent