BDBM370383 US10233189, Example 20::US10787457, Example 20::US11236096, Example 20

SMILES Nc1ncnc2n(CC3CCCC3)nc(C(=O)Nc3cc(Br)[nH]n3)c12

InChI Key InChIKey=GNMDVOZMYIYNJR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 370383   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370383(US10233189, Example 20 | US10787457, Example 20 | ...)
Affinity DataIC50:  5.83nMAssay Description:To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370383(US10233189, Example 20 | US10787457, Example 20 | ...)
Affinity DataIC50:  5.83nMAssay Description:To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370383(US10233189, Example 20 | US10787457, Example 20 | ...)
Affinity DataIC50:  1.00E+4nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against LCK kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370383(US10233189, Example 20 | US10787457, Example 20 | ...)
Affinity DataIC50:  117nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against SRC kinase activity, the price list of LabChip-series c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370383(US10233189, Example 20 | US10787457, Example 20 | ...)
Affinity DataIC50:  5.83nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent