BDBM371971 3-[(3-tert-Butyl-1,2,4-thiadiazol-5-yl)methyl]-8-(1H-indazole-5-carbonyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::US10239876, Example 45::US10435407, Example 45

SMILES CC(C)(C)c1nsc(CN2CN(c3ccccc3)C3(CCN(CC3)C(=O)c3ccc4[nH]ncc4c3)C2=O)n1

InChI Key InChIKey=SYWCXDMIXNCMEV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 371971   

TargetD(1A) dopamine receptor(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 371971BDBM371971(3-[(3-tert-Butyl-1,2,4-thiadiazol-5-yl)methyl]-8-(...)
Affinity DataIC50: 184nMAssay Description:This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetEpithelial discoidin domain-containing receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 371971BDBM371971(3-[(3-tert-Butyl-1,2,4-thiadiazol-5-yl)methyl]-8-(...)
Affinity DataIC50: 184nMAssay Description:This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
US Patent