BDBM372019 (RS)-3-(2-Oxo-1-phenylpyrrolidin-3-yl)-1-phenyl-8-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)-1,3,8-triazaspiro[4.5]decan-4-one::US10239876, Example 60::US10435407, Example 60

SMILES O=C(N1CCC2(CC1)N(CN(C1CCN(C1=O)c1ccccc1)C2=O)c1ccccc1)c1cnc2[nH]ncc2c1

InChI Key InChIKey=MGKDUWFEPDLKNZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 372019   

TargetEpithelial discoidin domain-containing receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 372019BDBM372019((RS)-3-(2-Oxo-1-phenylpyrrolidin-3-yl)-1-phenyl-8-...)
Affinity DataIC50: 59.5nMAssay Description:This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
US Patent

TargetD(1A) dopamine receptor(Human)
Hoffmann-La Roche

US Patent
LigandChemical structure of BindingDB Monomer ID 372019BDBM372019((RS)-3-(2-Oxo-1-phenylpyrrolidin-3-yl)-1-phenyl-8-...)
Affinity DataIC50: 59.5nMAssay Description:This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent